Optimal hematocrit for oxygenation of canine intestine.

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Optimal hematocrit for oxygenation of canine intestine.

To determine the direct effects of hematocrit on intestinal oxygen consumption and to determine whether an optimal hematocrit exists for intestinal oxygenation, we perfused isolated canine gut loops at a constant pressure (120 mm Hg) and varied hematocrit from 80% to 10%. As hematocrit fell, blood flow rose while arterial oxygen content fell. The regression of blood flow on hematocrit was linea...

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OBJECTIVE Oxygen tension in the brain is controlled by the microcirculatory supply of RBC, but the effect of non-Newtonian blood flow rheology on tissue oxygenation is not well characterized. This study assesses different biphasic blood flow models for predicting tissue oxygen tension as a function of microcirculatory hemodynamics. METHODS Two existing plasma-skimming laws are compared agains...

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PHYSIOLOGICAL SYSTEMS are characterized by multiple interdependent components that collectively subserve various processes and functions. In seeking better understanding of the performance of such complex systems, we must identify and evaluate alternative ways and operating schemes, comparing their predicted performance with goals or objectives of interest. Optimization entails selecting a bett...

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ژورنال

عنوان ژورنال: Circulation Research

سال: 1982

ISSN: 0009-7330,1524-4571

DOI: 10.1161/01.res.51.2.233